Research

Our research centers around mass spectrometry (MS) for omics measurements and biomarker discovery and validation.

MS and proteomics methods for chemically-modified proteins and peptides

  • Chemical principles of endogenous and exogenous omic┬áreactions
    • Scaling analysis of proteome-wide reactions and chemical proteomics
  • Novel chemical reagents for MS-based proteomics measurements
    • Design and synthesis of reagents enabling new MS analysis with improved sample throughput and signal enhancement
    • Novel chemical probes and proteomics methods for discovery of proteins modified with small molecules
    • Fragment-ion based analysis for MS of modified proteins and peptides
  • MS of the in-cell structure of proteins
    • Reversed fast photochemical oxidation of proteins (FPOP)-multiple reaction monitoring (MRM) MS
    • Expression, trafficking, structure and function of cystic fibrosis transmembrane conductance regulator

Discovery and development of molecular markers

  • Ultrathroughput MS (uMS) for biomarker research and applications
  • Bioactivity-driven (targeted) discovery of molecules in metabolome
  • New methods of separation and MS for analyzing lipids and metabolites